UNDERSTANDING
THE CAUSE

Atopic dermatitis - From the inside out


If a person suffers with a chronic skin condition1, it may be atopic dermatitis, the commonest form of eczema. If someone struggles with frequent, reoccurring flare-ups, there may be an underlying cause within their body.2

With atopic dermatitis, even when the skin looks clear, inflammation may still be active under the surface, and a next flare-up may be waiting to return.3 Some people, however, always show signs of the disease.

The most obvious sign of atopic dermatitis is dry, itchy skin. Flare-ups are different for every person and can appear all over the body. Some other common external symptoms include4:

*Whilst this is an example of a common symptom, each individual case of atopic dermatitis will vary and therefore, this image acts as an example, not a comparator.

Scratching the Surface

With atopic dermatitis, the immune system is highly sensitive and can react to even the smallest irritants or substances that cause an allergic reaction.5 This reaction can cause excess inflammation underneath the skin, which may lead to frequent flare-ups. The rashes you see on the surface are just the visible signs of a deeper inflammatory disease.


1. ITCH

In people with atopic dermatitis, immune cells in the deeper layers of your skin send inflammatory signals to the surface, causing the itchy rash.4

2. SCRATCH

When you scratch, you can break down the outer layer of skin which allows germs, viruses and allergens to get in.4

4. RELEASE OF INFLAMMATORY SIGNALS

The more you scratch, the more your skin barrier breaks down, and the itch-scratch cycle continues.7

3. DAMAGED SKIN

In response to these invaders, the immune system continues to send signals to the surface, causing even more redness and itching.6

4. RELEASE OF INFLAMMATORY SIGNALS

The more you scratch, the more your skin barrier breaks down, and the itch-scratch cycle continues.7